Researchers at Duke University have identified ALDH4A1, a mitochondrial enzyme, as a powerful defender against cancer. This protein ensures healthy cells efficiently produce energy by facilitating pyruvate import into mitochondria.
But here’s where it gets interesting—many tumors suppress ALDH4A1, forcing cells into glycolysis, a low-efficiency energy pathway that cancer thrives on. By restoring ALDH4A1, scientists disrupted this process, slowing tumor growth without harming normal cells.
This breakthrough paves the way for treatments that fuel normal tissue while cutting off cancer’s power supply, making ALDH4A1 a promising target for future therapies.
#CancerResearch #CellBiology #MedicalBreakthrough #ALDH4A1 #DukeUniversity
But here’s where it gets interesting—many tumors suppress ALDH4A1, forcing cells into glycolysis, a low-efficiency energy pathway that cancer thrives on. By restoring ALDH4A1, scientists disrupted this process, slowing tumor growth without harming normal cells.
This breakthrough paves the way for treatments that fuel normal tissue while cutting off cancer’s power supply, making ALDH4A1 a promising target for future therapies.
#CancerResearch #CellBiology #MedicalBreakthrough #ALDH4A1 #DukeUniversity
Researchers at Duke University have identified ALDH4A1, a mitochondrial enzyme, as a powerful defender against cancer. This protein ensures healthy cells efficiently produce energy by facilitating pyruvate import into mitochondria.
But here’s where it gets interesting—many tumors suppress ALDH4A1, forcing cells into glycolysis, a low-efficiency energy pathway that cancer thrives on. By restoring ALDH4A1, scientists disrupted this process, slowing tumor growth without harming normal cells.
This breakthrough paves the way for treatments that fuel normal tissue while cutting off cancer’s power supply, making ALDH4A1 a promising target for future therapies.
#CancerResearch #CellBiology #MedicalBreakthrough #ALDH4A1 #DukeUniversity
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