Hera From The Lord of the Rings: The War of the Rohirrim

Cosplayer:

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#thelordoftherings #thewaroftherohirrim #hera #costume #cos #cosplay #cosplayer #cosplaygirl

In a landmark medical advancement, researchers at Newcastle University have successfully created a 3D-printed human cornea using stem cells, collagen, and alginate to form a bio-ink. This innovation offers renewed hope to more than 10 million people globally who suffer from corneal blindness due to disease, trauma, or infection. The 3D printing process can produce custom-shaped corneas in under 10 minutes, tailored precisely to each patient using a simple eye scan.

What makes this technology even more promising is its potential to ease the global shortage of donor corneas. Since bio-printed corneas are derived from a patient’s own stem cells, the risk of rejection could be significantly reduced. While clinical trials and regulatory hurdles remain before these corneas can be widely used in patients, this achievement marks a massive step toward revolutionizing eye care and restoring sight for millions.

#3DPrinting #StemCellTherapy #VisionRestoration #MedicalInnovation
#Bioengineering

Mouth-taping — where individuals tape their mouths shut before sleep to encourage nasal breathing — has gained popularity on TikTok and other social media platforms.

It’s promoted as a remedy for snoring, sleep apnea, and even general sleep improvement.

Scientific Review Findings:
A 2024 review of 10 clinical studies examined the efficacy and safety of this practice.

The findings revealed minimal to no consistent evidence that mouth-taping provides significant benefits for conditions like snoring or obstructive sleep apnea (OSA).

The studies often had small sample sizes, lacked long-term data, and varied in methodology.

Potential Risks Identified:

Breathing Obstruction: Especially for people with undiagnosed or moderate-to-severe OSA, taping the mouth could worsen oxygen deprivation during sleep.

Panic or Anxiety: Some users report feeling claustrophobic or anxious.

Skin Irritation: Prolonged taping may cause rashes or allergies around the mouth area.

Expert Consensus:

Organizations such as the American Academy of Sleep Medicine caution against self-experimenting with unproven TikTok trends.

They recommend CPAP therapy or medical consultation for diagnosed sleep apnea rather than relying on DIY solutions like mouth-taping.

In a medical breakthrough that could reshape the future of HIV treatment, researchers have successfully used CRISPR/Cas9 gene-editing technology to eliminate HIV from human T-cells—and in follow-up lab tests, the virus did not return. This marks a major shift from traditional antiretroviral therapies, which only suppress viral replication but cannot remove the virus embedded in the host's DNA. By directly excising the proviral HIV-1 genome from immune cells, this technique targets the root of the infection—something decades of treatments have struggled to achieve.

What makes this discovery even more promising is that the edited immune cells were not only HIV-free but also resistant to reinfection. That suggests a future where patients might receive a one-time treatment capable of permanently curing HIV. While human clinical trials are still in early stages and much research remains, the results signal hope for millions living with the virus. If proven safe and effective in broader applications, this could become one of the most transformative moments in medical history.

#HIVCure #GeneEditing #CRISPR #MedicalBreakthrough #FutureOfMedicine

Scientists at the University of Sunderland, led by Dr. Maria Teresa Borrello, have developed two experimental drugs—DR-3 and FDR2—that target the enzyme HDAC6.

These drugs have shown promise in halting or reversing liver fibrosis, a condition characterized by the accumulation of scar tissue in the liver.

Research Overview

The research, published in The FEBS Journal, focuses on the role of HDAC6 in liver fibrosis.

HDAC6 is involved in regulating inflammation and the activation of hepatic stellate cells, which are responsible for producing collagen and contributing to scar tissue formation.

By inhibiting HDAC6, the experimental drugs aim to reduce inflammation and prevent the activation of these stellate cells, thereby mitigating fibrosis progression.

Laboratory Findings

In laboratory settings, the HDAC6 inhibitors DR-3 and FDR2 demonstrated high selectivity for HDAC6 over other histone deacetylases.

They effectively reduced markers of hepatic stellate cell activation and fibrogenic gene expression.

Additionally, these compounds increased acetylation of α-tubulin and suppressed TGF-β1-induced SMAD signaling, which are key pathways in fibrosis development.

Ex Vivo Human Liver Models

The efficacy of DR-3 and FDR2 was further validated using human precision-cut liver slices (hPCLS), an ex vivo model that closely mimics human liver tissue.

Treatment with these inhibitors resulted in reduced fibrogenic protein levels and collagen deposition, indicating their potential to reverse existing fibrosis.

Importantly, these effects were achieved without significant toxicity to the liver tissue.

Clinical Implications

The British Liver Trust has welcomed these findings, highlighting their potential to transform care for the UK's estimated two million liver fibrosis patients, many of whom are diagnosed at advanced stages of the disease.

While these results are promising, the drugs are still in the experimental phase and have not yet undergone human clinical trials. Nevertheless, they offer a targeted therapeutic approach that could eventually become a lifesaving treatment worldwide.