Easy Cheesy Lasagna

Creamy, Gooey, and Effortless Cheesy Lasagna

Ingredients:

9 lasagna noodles

2 cups ricotta cheese

3 cups shredded mozzarella cheese

1 cup grated Parmesan cheese

2 cups marinara sauce

1 egg

2 cloves garlic, minced

1 teaspoon dried basil

1 teaspoon dried oregano

Salt and pepper to taste

Fresh basil leaves for garnish (optional)

Directions:

Preheat oven to 375°F (190°C). Cook lasagna noodles according to package instructions until al dente. Drain and set aside.

In a medium bowl, combine ricotta cheese, egg, garlic, dried basil, oregano, salt, and pepper. Mix well.

Spread a thin layer of marinara sauce on the bottom of a 9x13-inch baking dish.

Layer 3 cooked lasagna noodles over the sauce. Spread one-third of the ricotta mixture over the noodles, then sprinkle with one cup of mozzarella and a little Parmesan.

Repeat the layers two more times, ending with mozzarella and Parmesan on top.

Cover the dish with aluminum foil and bake for 25 minutes. Remove the foil and bake for an additional 15 minutes until the cheese is bubbly and golden.

Let the lasagna cool for 10 minutes before serving. Garnish with fresh basil leaves if desired.

Prep Time: 15 minutes | Cooking Time: 40 minutes | Total Time: 55 minutes
Kcal: Approximately 450 kcal per serving | Servings: 6 servings

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Dive into layers of cheesy goodness with this Easy Cheesy Lasagna! Perfect for comforting family dinners and impressing guests.

Scientists at the University of Sunderland, led by Dr. Maria Teresa Borrello, have developed two experimental drugs—DR-3 and FDR2—that target the enzyme HDAC6.

These drugs have shown promise in halting or reversing liver fibrosis, a condition characterized by the accumulation of scar tissue in the liver.

Research Overview

The research, published in The FEBS Journal, focuses on the role of HDAC6 in liver fibrosis.

HDAC6 is involved in regulating inflammation and the activation of hepatic stellate cells, which are responsible for producing collagen and contributing to scar tissue formation.

By inhibiting HDAC6, the experimental drugs aim to reduce inflammation and prevent the activation of these stellate cells, thereby mitigating fibrosis progression.

Laboratory Findings

In laboratory settings, the HDAC6 inhibitors DR-3 and FDR2 demonstrated high selectivity for HDAC6 over other histone deacetylases.

They effectively reduced markers of hepatic stellate cell activation and fibrogenic gene expression.

Additionally, these compounds increased acetylation of α-tubulin and suppressed TGF-β1-induced SMAD signaling, which are key pathways in fibrosis development.

Ex Vivo Human Liver Models

The efficacy of DR-3 and FDR2 was further validated using human precision-cut liver slices (hPCLS), an ex vivo model that closely mimics human liver tissue.

Treatment with these inhibitors resulted in reduced fibrogenic protein levels and collagen deposition, indicating their potential to reverse existing fibrosis.

Importantly, these effects were achieved without significant toxicity to the liver tissue.

Clinical Implications

The British Liver Trust has welcomed these findings, highlighting their potential to transform care for the UK's estimated two million liver fibrosis patients, many of whom are diagnosed at advanced stages of the disease.

While these results are promising, the drugs are still in the experimental phase and have not yet undergone human clinical trials. Nevertheless, they offer a targeted therapeutic approach that could eventually become a lifesaving treatment worldwide.

Looking for a delicious low-carb twist on a classic dish? This Keto Chicken Fried Steak is crispy, savory, and oh-so-satisfying!

Ingredients:
- 1 pound cube steak
- 1 cup almond flour
- 1 teaspoon garlic powder
- 1 teaspoon onion powder
- 1 teaspoon paprika
- 1 teaspoon salt
- 1/2 teaspoon black pepper
- 2 large eggs
- 1/4 cup heavy cream
- 1/4 cup pork rinds, crushed (optional, for extra crunch)
- 1/4 cup coconut oil or avocado oil (for frying)

Directions:
1. Start by preheating your oven to 200°F. This way, you can keep those beautifully cooked steaks warm while you finish frying.
2. In a shallow bowl, mix together the almond flour, garlic powder, onion powder, paprika, salt, and black pepper. Give it a good stir to combine all those zesty flavors.
3. In another bowl, whisk the eggs and heavy cream together until they're well blended and ready for coating.
4. Time to dip! Take each cube steak and first immerse it in the egg mixture, letting any excess drip off, then coat it thoroughly in the almond flour mixture. If you’re feeling adventurous, press it into the crushed pork rinds for an extra crunch.
5. Heat your choice of coconut oil or avocado oil in a large skillet over medium-high heat. You want that oil nice and hot!
6. Carefully add the coated cube steaks to the skillet. Fry them for about 3-4 minutes on each side until they turn a gorgeous golden brown and are cooked through.
7. Once cooked, transfer the steaks to a baking sheet and pop them in the oven to keep warm while you finish the rest.
8. Serve these hot, and for an extra treat, why not pair with a keto-friendly gravy or a side of steamed veggies?

Nutritional Values (per serving):
- Serving Size: 1 steak
- Calories: 420
- Protein: 35g
- Fat: 30g
- Carbohydrates: 8g
- Fiber: 4g
- Net Carbs: 4g

Enjoy your keto-friendly feast! #KetoRecipes #LowCarb #EatClean #ChickenFriedSteak #HealthyEating

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