A single dose of psilocybin, the active compound in magic mushrooms, has been shown to provide long-lasting relief from depression and anxiety in people with cancer, according to growing clinical evidence.

This psychedelic compound appears to restructure neural pathways related to emotional processing, resulting in improved mood, reduced existential distress, and enhanced quality of life—even months or years after the treatment.

Scientific Findings:

In landmark clinical trials (including studies from Johns Hopkins and NYU), up to 80% of participants reported significant decreases in depression and anxiety after just one guided psilocybin session.

The psychological improvements persisted for 6 months to over 4 years in many cases.

Brain imaging studies revealed that psilocybin reduces activity in the brain’s default mode network, often associated with negative rumination and self-focus.

Patients frequently report profound, meaningful, or spiritual experiences during the sessions, which may help them reframe their understanding of death and suffering.

What Makes It Different:

Unlike conventional antidepressants that require daily use and take weeks to work, psilocybin offers rapid onset and sustained results after just a single high-dose session—conducted with professional psychological support.

Caution:

This therapy is not yet legal or widely available outside of clinical trials in most countries.

It should only be administered under medical supervision, as it involves intense psychological experiences that can be distressing without guidance.

Pretty is my Favorite Mood

B Keith Will

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A new study has shown that global mercury levels in rivers have increased two- to three-fold since around 1850, the onset of the Industrial Revolution.

Mercury, particularly in its organic form (methylmercury), is a powerful neurotoxin that primarily threatens human health through contaminated fish consumption.

Rivers, which play a vital role in providing drinking water and food and in transporting nutrients to the ocean, have become significant conduits for mercury pollution.

Using a global model, researchers estimated that rivers carried about 390 megagrams (metric tons) of mercury to the oceans annually in preindustrial times.

This baseline serves as a critical reference point to understand human-induced changes. In present-day conditions, that number has more than doubled, largely due to mercury emissions from coal burning, gold mining, industrial processes, and deforestation.

The study also emphasizes that mercury concentrations in rivers respond quickly to human activities, making them useful indicators for tracking pollution control measures.

By understanding these patterns and comparing them over time, policymakers can better design and evaluate environmental regulations aimed at reducing mercury pollution.

These findings align with existing research by institutions like the UNEP Global Mercury Assessment and efforts under the Minamata Convention on Mercury, which aim to reduce global mercury emissions.

However, this study adds value by quantifying the historical and present-day riverine mercury flux, offering a global baseline for restoration and policy goals.

A groundbreaking study published in Nature Medicine reveals that aging doesn't happen gradually, but in distinct biological waves. Researchers analyzed blood plasma from over 4,000 individuals ranging in age from 18 to 95 and found sharp shifts in protein levels linked to key bodily functions — at around ages 34, 60, and 78. These shifts affect metabolism, cardiovascular health, immune response, and even brain function, indicating our bodies may enter new biological "chapters" at those ages.

This discovery suggests that aging is more punctuated than previously thought — with specific turning points where molecular changes spike. Understanding these aging milestones could help scientists develop age-specific therapies or lifestyle interventions to delay disease onset and optimize longevity. It’s a fascinating reminder that aging isn’t just a slow decline — it’s a sequence of transformations, each with its own challenges and potential.

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Colorectal cancer (commonly called bowel cancer) is indeed increasing at an alarming rate among young people.

According to multiple studies including those published in Nature Medicine and reported by major outlets like The Guardian and NBC News:

Rates of early-onset colorectal cancer (EOCRC)—especially in those under 50—are doubling roughly every decade.

A recent international study of 981 tumor samples from 11 countries found a bacterial toxin called colibactin, made by certain E. coli strains, was significantly more common in younger patients' tumors (under 40 years old) than in older adults.

Colibactin damages DNA and may silently initiate cancer development years before diagnosis—potentially beginning in childhood.

While traditional risk factors (obesity, diet, sedentary life) still matter, this research shifts focus to gut microbiome health in early life.

Researchers are now exploring how to intervene—via probiotics, early-life nutrition, or gut-friendly interventions—to reduce long-term cancer risk.

Although colibactin’s presence is not confirmed as the sole cause, it’s a crucial new lead in understanding this generational shift.