Swiss Zürcher Geschnetzeltes mit Rösti – Creamy Veal with Potato Rösti

A classic from Zürich, this dish features thin slices of veal in a white wine cream sauce, paired with crisp, golden potato rösti.

Ingredients (Serves 2):

* 300g veal, thinly sliced
* 150ml cream
* 100ml dry white wine
* 1 onion, finely chopped
* 1 tsp flour
* Butter, salt, pepper
* For Rösti: 2 large potatoes, grated, seasoned, and pan-fried

Instructions:

1. Sear veal quickly in butter. Remove.
2. Sauté onion, add flour, deglaze with wine. Reduce, then stir in cream.
3. Return veal to pan, cook until just heated through. Season.
4. Serve with crispy rösti on the side.

Swiss Tip:
Use day-old boiled potatoes for rösti to improve crispiness.

Someone is showing off to the outside world how prepared they are

Easy Cheesy Lasagna

Creamy, Gooey, and Effortless Cheesy Lasagna

Ingredients:

9 lasagna noodles

2 cups ricotta cheese

3 cups shredded mozzarella cheese

1 cup grated Parmesan cheese

2 cups marinara sauce

1 egg

2 cloves garlic, minced

1 teaspoon dried basil

1 teaspoon dried oregano

Salt and pepper to taste

Fresh basil leaves for garnish (optional)

Directions:

Preheat oven to 375°F (190°C). Cook lasagna noodles according to package instructions until al dente. Drain and set aside.

In a medium bowl, combine ricotta cheese, egg, garlic, dried basil, oregano, salt, and pepper. Mix well.

Spread a thin layer of marinara sauce on the bottom of a 9x13-inch baking dish.

Layer 3 cooked lasagna noodles over the sauce. Spread one-third of the ricotta mixture over the noodles, then sprinkle with one cup of mozzarella and a little Parmesan.

Repeat the layers two more times, ending with mozzarella and Parmesan on top.

Cover the dish with aluminum foil and bake for 25 minutes. Remove the foil and bake for an additional 15 minutes until the cheese is bubbly and golden.

Let the lasagna cool for 10 minutes before serving. Garnish with fresh basil leaves if desired.

Prep Time: 15 minutes | Cooking Time: 40 minutes | Total Time: 55 minutes
Kcal: Approximately 450 kcal per serving | Servings: 6 servings

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Dive into layers of cheesy goodness with this Easy Cheesy Lasagna! Perfect for comforting family dinners and impressing guests.

Scientists at the University of Sunderland, led by Dr. Maria Teresa Borrello, have developed two experimental drugs—DR-3 and FDR2—that target the enzyme HDAC6.

These drugs have shown promise in halting or reversing liver fibrosis, a condition characterized by the accumulation of scar tissue in the liver.

Research Overview

The research, published in The FEBS Journal, focuses on the role of HDAC6 in liver fibrosis.

HDAC6 is involved in regulating inflammation and the activation of hepatic stellate cells, which are responsible for producing collagen and contributing to scar tissue formation.

By inhibiting HDAC6, the experimental drugs aim to reduce inflammation and prevent the activation of these stellate cells, thereby mitigating fibrosis progression.

Laboratory Findings

In laboratory settings, the HDAC6 inhibitors DR-3 and FDR2 demonstrated high selectivity for HDAC6 over other histone deacetylases.

They effectively reduced markers of hepatic stellate cell activation and fibrogenic gene expression.

Additionally, these compounds increased acetylation of α-tubulin and suppressed TGF-β1-induced SMAD signaling, which are key pathways in fibrosis development.

Ex Vivo Human Liver Models

The efficacy of DR-3 and FDR2 was further validated using human precision-cut liver slices (hPCLS), an ex vivo model that closely mimics human liver tissue.

Treatment with these inhibitors resulted in reduced fibrogenic protein levels and collagen deposition, indicating their potential to reverse existing fibrosis.

Importantly, these effects were achieved without significant toxicity to the liver tissue.

Clinical Implications

The British Liver Trust has welcomed these findings, highlighting their potential to transform care for the UK's estimated two million liver fibrosis patients, many of whom are diagnosed at advanced stages of the disease.

While these results are promising, the drugs are still in the experimental phase and have not yet undergone human clinical trials. Nevertheless, they offer a targeted therapeutic approach that could eventually become a lifesaving treatment worldwide.

Spanish Zarzuela de Mariscos – Catalan Seafood Medley

A luxurious seafood stew from Catalonia, Zarzuela is made with a medley of shellfish and fish in a saffron-tomato-white wine sauce, often served at special occasions.

Ingredients (Serves 4):

* 200g shrimp
* 200g mussels
* 200g clams
* 300g firm white fish (hake, monkfish)
* 1 onion, chopped
* 2 garlic cloves, minced
* 2 tomatoes, peeled and chopped
* 100ml white wine
* 1 pinch saffron threads
* Olive oil, salt, pepper, parsley

Instructions:

1. Sauté onion and garlic in olive oil. Add tomatoes and saffron, cook until thickened.
2. Pour in white wine and simmer.
3. Add fish, then mussels, clams, and shrimp. Cover and steam until shellfish open and fish is cooked.
4. Season and garnish with parsley. Serve with toasted bread.

Catalan Tip:
For extra richness, blend a paste of almonds and garlic (picada) and stir in before serving.