**Creamy Mushroom Keto Casserole**
Indulge in this rich and savory keto casserole that’s perfect for any night of the week! #KetoEats #LowCarb

**Ingredients:**

- 1 pound of fresh mushrooms, sliced
- 1 medium onion, diced
- 3 cloves garlic, minced
- 1 cup heavy cream
- 1 cup shredded mozzarella cheese
- 1 cup grated Parmesan cheese
- 2 tablespoons olive oil
- 1 teaspoon dried thyme
- 1 teaspoon salt
- 1/2 teaspoon black pepper
- 1 cup cooked chicken, shredded (optional)
- 1 cup spinach (optional)

**Directions:**

1. Preheat your oven to 375°F (190°C).
2. In a large skillet, heat the olive oil over medium heat. Add the diced onion and sauté until translucent, about 3-4 minutes.
3. Toss in the minced garlic and sliced mushrooms. Sauté until the mushrooms are softened and have released their moisture, around 5-7 minutes.
4. Stir in the heavy cream, dried thyme, salt, and black pepper, cooking for an additional 2-3 minutes until everything is warmed through.
5. If you're adding chicken and spinach, throw them into the skillet now and mix until combined.
6. Remove the skillet from the heat and incorporate half of the mozzarella and half of the Parmesan cheese, stirring until melted and well combined.
7. Transfer this creamy mixture into a greased 9x13-inch baking dish. Sprinkle the remaining mozzarella and Parmesan cheese on top.
8. Bake in your preheated oven for 20-25 minutes, or until the cheese is all bubbly and golden brown.
9. Let it cool for a few minutes before diving in!

**Nutritional Values (per serving, based on 6 servings):**
- Calories: 320
- Fat: 25g
- Carbohydrates: 4g
- Protein: 20g

**Serving Size:** 1/6 of the casserole

Delight in this creamy, cheesy goodness that fits perfectly into your keto lifestyle! #KetoCasserole #MushroomLovers #HealthyEating #ComfortFood #Foodie

Sweet Onion Dip

Creamy Caramelized Sweet Onion Dip

Ingredients:

2 large sweet onions, thinly sliced

2 tablespoons butter

1 tablespoon olive oil

1/2 teaspoon salt

1 cup sour cream

1/2 cup mayonnaise

1 teaspoon Worcestershire sauce

1/2 teaspoon garlic powder

Fresh chives or parsley for garnish

Directions:

In a large skillet, heat butter and olive oil over medium heat. Add the sliced onions and salt.

Cook slowly, stirring occasionally, until onions are caramelized and golden brown, about 25-30 minutes.

Remove onions from heat and let cool slightly.

In a mixing bowl, combine sour cream, mayonnaise, Worcestershire sauce, and garlic powder.

Stir in the caramelized onions until fully combined.

Chill the dip in the refrigerator for at least 1 hour to let flavors meld.

Garnish with chopped fresh chives or parsley before serving.

Prep Time: 10 minutes | Cooking Time: 30 minutes | Total Time: 40 minutes
Kcal: Approximately 120 kcal per serving (based on 8 servings) | Servings: 8 servings

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Creamy, sweet, and packed with flavor—this Sweet Onion Dip is your new go-to for parties and snacks! Perfect with chips or veggies.

Mouth-taping — where individuals tape their mouths shut before sleep to encourage nasal breathing — has gained popularity on TikTok and other social media platforms.

It’s promoted as a remedy for snoring, sleep apnea, and even general sleep improvement.

Scientific Review Findings:
A 2024 review of 10 clinical studies examined the efficacy and safety of this practice.

The findings revealed minimal to no consistent evidence that mouth-taping provides significant benefits for conditions like snoring or obstructive sleep apnea (OSA).

The studies often had small sample sizes, lacked long-term data, and varied in methodology.

Potential Risks Identified:

Breathing Obstruction: Especially for people with undiagnosed or moderate-to-severe OSA, taping the mouth could worsen oxygen deprivation during sleep.

Panic or Anxiety: Some users report feeling claustrophobic or anxious.

Skin Irritation: Prolonged taping may cause rashes or allergies around the mouth area.

Expert Consensus:

Organizations such as the American Academy of Sleep Medicine caution against self-experimenting with unproven TikTok trends.

They recommend CPAP therapy or medical consultation for diagnosed sleep apnea rather than relying on DIY solutions like mouth-taping.

Easy Cheesy Lasagna

Creamy, Gooey, and Effortless Cheesy Lasagna

Ingredients:

9 lasagna noodles

2 cups ricotta cheese

3 cups shredded mozzarella cheese

1 cup grated Parmesan cheese

2 cups marinara sauce

1 egg

2 cloves garlic, minced

1 teaspoon dried basil

1 teaspoon dried oregano

Salt and pepper to taste

Fresh basil leaves for garnish (optional)

Directions:

Preheat oven to 375°F (190°C). Cook lasagna noodles according to package instructions until al dente. Drain and set aside.

In a medium bowl, combine ricotta cheese, egg, garlic, dried basil, oregano, salt, and pepper. Mix well.

Spread a thin layer of marinara sauce on the bottom of a 9x13-inch baking dish.

Layer 3 cooked lasagna noodles over the sauce. Spread one-third of the ricotta mixture over the noodles, then sprinkle with one cup of mozzarella and a little Parmesan.

Repeat the layers two more times, ending with mozzarella and Parmesan on top.

Cover the dish with aluminum foil and bake for 25 minutes. Remove the foil and bake for an additional 15 minutes until the cheese is bubbly and golden.

Let the lasagna cool for 10 minutes before serving. Garnish with fresh basil leaves if desired.

Prep Time: 15 minutes | Cooking Time: 40 minutes | Total Time: 55 minutes
Kcal: Approximately 450 kcal per serving | Servings: 6 servings

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Dive into layers of cheesy goodness with this Easy Cheesy Lasagna! Perfect for comforting family dinners and impressing guests.

Scientists at the University of Sunderland, led by Dr. Maria Teresa Borrello, have developed two experimental drugs—DR-3 and FDR2—that target the enzyme HDAC6.

These drugs have shown promise in halting or reversing liver fibrosis, a condition characterized by the accumulation of scar tissue in the liver.

Research Overview

The research, published in The FEBS Journal, focuses on the role of HDAC6 in liver fibrosis.

HDAC6 is involved in regulating inflammation and the activation of hepatic stellate cells, which are responsible for producing collagen and contributing to scar tissue formation.

By inhibiting HDAC6, the experimental drugs aim to reduce inflammation and prevent the activation of these stellate cells, thereby mitigating fibrosis progression.

Laboratory Findings

In laboratory settings, the HDAC6 inhibitors DR-3 and FDR2 demonstrated high selectivity for HDAC6 over other histone deacetylases.

They effectively reduced markers of hepatic stellate cell activation and fibrogenic gene expression.

Additionally, these compounds increased acetylation of α-tubulin and suppressed TGF-β1-induced SMAD signaling, which are key pathways in fibrosis development.

Ex Vivo Human Liver Models

The efficacy of DR-3 and FDR2 was further validated using human precision-cut liver slices (hPCLS), an ex vivo model that closely mimics human liver tissue.

Treatment with these inhibitors resulted in reduced fibrogenic protein levels and collagen deposition, indicating their potential to reverse existing fibrosis.

Importantly, these effects were achieved without significant toxicity to the liver tissue.

Clinical Implications

The British Liver Trust has welcomed these findings, highlighting their potential to transform care for the UK's estimated two million liver fibrosis patients, many of whom are diagnosed at advanced stages of the disease.

While these results are promising, the drugs are still in the experimental phase and have not yet undergone human clinical trials. Nevertheless, they offer a targeted therapeutic approach that could eventually become a lifesaving treatment worldwide.